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Article

Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.

The Journal of biological chemistry - 25 Aug 2006

Bernier Virginie, Stocco Rino, Bogusky Michael J, Joyce Joseph G, Parachoniak Christine, Grenier Karl, Arget Michael, Mathieu Marie-Claude, O'Neill Gary P, Slipetz Deborah, Crackower Michael A, Tan Christopher M, Therien Alex G

Abstract excerpt

Neuropeptide S (NPS) and its receptor (NPSR) are thought to have a role in asthma pathogenesis; a number of single nucleotide polymorphisms within NPSR have been shown to be associated with an increased prevalance of asthma. One such single nucleotide polymorphism leads to the missense mutation N...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16790440
DOI: 10.1074/jbc.M603691200

Genes

NPS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16790440-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Structure-function relationships in the neuropeptide S receptor: molecular consequences of the asthma-associated mutation N107I.PMID 16790440Read ↗

Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma.Semantic proximity Read ↗

Pharmacological characterization of human and murine neuropeptide s receptor variants.Semantic proximity Read ↗

Mutagenesis studies of neuropeptide S identify a suitable peptide tracer for neuropeptide S receptor binding studies and peptides selectively activating the I(107) variant of human neuropeptide S receptor.Semantic proximity Read ↗

A single-nucleotide polymorphism of human neuropeptide s gene originated from Europe shows decreased bioactivity.Semantic proximity Read ↗

Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1).Semantic proximity Read ↗

Neuropeptide S Receptor 1 variant (I107N) regulates behavioral characteristics and NPS effect in mice in a sex-dependent manner.Semantic proximity Read ↗

Conformation-activity relationship of neuropeptide S and some structural mutants: helicity affects their interaction with the receptor.Semantic proximity Read ↗

The asthma candidate gene NPSR1 mediates isoform specific downstream signalling.Semantic proximity Read ↗

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Neuropeptide S receptor induces neuropeptide expression and associates with intermediate phenotypes of functional gastrointestinal disorders.Semantic proximity Read ↗

Single amino acid substitutions modulate the function of α9α10 nicotinic acetylcholine receptor.Semantic proximity Read ↗

The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response.Semantic proximity Read ↗

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