Article
Promoter mutations and cellular distribution of telomerase in non-clear cell and clear cell hepatocellular carcinoma.
Oncotarget - 18 Apr 2017
Huang Wan, Zhou Weiping, Li Can, Yang Yuan, Shang Yu-Kui, Chen Changsheng, Zhang Jing, Yao Rui, Wang Pei, Wen Wen, Liu Han-Qiang, Wang Ling, Li Xia, Bian Huijie, Chen Zhi-Nan
Abstract excerpt
Reactivation of telomerase is a critical step in the development of hepatocellular carcinoma (HCC). Here we identified the frequency of mutations in telomerase reverse transcriptase (TERT) promoter was 34% in non-clear cell HCC (NCCHCC, n = 259) and 26.3% in clear cell HCC (CCHCC, n = 57). The mutations were independently associated with poor recurrence-free survival of HCCs. Interestingly immunohistochemical...
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