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Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinoma

19 May 2017

Abstract excerpt

Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the accumulation of genetic alterations in the human genome. Nucleotide changes in coding regions (i.e. TP53, CTNNB1, ARID1A and ARID2) as well as in non-coding regions (i.e. TERT promoter) are considered cancer drivers for HCC development...

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PMID: 28529542
DOI: 10.1186/s13027-017-0138-5

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