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Article

Telomerase in differentiated thyroid cancer: promoter mutations, expression and localization.

Molecular and cellular endocrinology - 5 Jan 2015

Muzza Marina, Colombo Carla, Rossi Stefania, Tosi Delfina, Cirello Valentina, Perrino Michela, De Leo Simone, Magnani Elisa, Pignatti Elisa, Vigo Beatrice, Simoni Manuela, Bulfamante Gaetano, Vicentini Leonardo, Fugazzola Laura

Abstract excerpt

Telomerase-reverse-transcriptase (TERT) promoter mutations have been recently described in tumors. In the present large series, TERT mutations were found in 12% of papillary thyroid cancers (PTCs) and in 14% of follicular thyroid cancers (FTCs), and were found to significantly correlate with older age at diagnosis and poorer outcome. Interestingly, the prognostic value of TERT mutations resulted to be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25448848
DOI: 10.1016/j.mce.2014.10.019

Genes

TERT
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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