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Article

Tumor specific mutations in TERT promoter and CTNNB1 gene in hepatitis B and hepatitis C related hepatocellular carcinoma.

Oncotarget - 23 Aug 2016

Pezzuto Francesca, Izzo Francesco, Buonaguro Luigi, Annunziata Clorinda, Tatangelo Fabiana, Botti Gerardo, Buonaguro Franco M, Tornesello Maria Lina

Abstract excerpt

Recurrent somatic mutations in the promoter region of telomerase reverse transcriptase (TERT) gene and in the exon 3 of CTNNB1 gene have been recognized as common events in hepatocellular carcinoma (HCC) with variable frequencies depending on etiology and geographical region. We have analyzed TERT promoter and CTNNB1 gene mutations in 122 cases of hepatitis B (HBV) and hepatitis C (HCV) related HCCs, in 7 cases...

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Topics

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Share to beta Catenin
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B

Share to Hepatitis C

Share to Liver Neoplasms

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Share to Promoter Regions, Genetic

Share to Telomerase

Source

Open in PubMed Open full text

Identifiers

PMID: 27276713
DOI: 10.18632/oncotarget.9801
PMCID: PMC5342339

Genes

CTNNB1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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