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Article

Characterization and Impact of TERT Promoter Region Mutations on Clinical Outcome in Renal Cell Carcinoma.

European urology focus - 1 Jul 2019

Casuscelli Jozefina, Becerra Maria F, Manley Brandon J, Zabor Emily C, Reznik Ed, Redzematovic Almedina, Arcila Maria E, Tennenbaum Daniel M, Ghanaat Mazyar, Kashan Mahyar, Stief Christian G, Carlo Maria, Voss Martin H, Feldman Darren R, Motzer Robert J, Chen Yingbei, Reuter Victor E, Coleman Jonathan A, Russo Paul, Hsieh James J, Hakimi Abraham Ari

Abstract excerpt

BACKGROUND: Mutations in the promoter region of the TERT gene have been detected in a variety of cancers. These mutations can potentially lead to unlimited cell divisions and result in poor clinical prognosis. OBJECTIVE: To determine the role and relevance of TERT promoter region mutations in both clear cell (ccRCC) and non-clear cell (nccRCC) renal cell carcinoma using ultra-deep and whole-genome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28951115
DOI: 10.1016/j.euf.2017.09.008
PMCID: PMC5984188

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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