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Article

TERT promoter mutations in clear cell renal cell carcinoma.

International journal of cancer - 15 May 2015

Hosen Ismail, Rachakonda P Sivaramakrishna, Heidenreich Barbara, Sitaram Raviprakash T, Ljungberg Börje, Roos Göran, Hemminki Kari, Kumar Rajiv

Abstract excerpt

We screened promoter region of the telomerase reverse transcriptase (TERT) for activating somatic mutations in 188 tumors from patients with clear cell renal cell carcinoma (ccRCC). Twelve tumors (6.4%) carried a mutation within the core promoter region of the gene. The mutations were less frequent in high grade tumors compared to low grade tumors [odds ratio (OR) = 0.15, 95% confidence interval (CI) = 0.03-0.72,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25331263
DOI: 10.1002/ijc.29279

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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