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Article

Steady-State Kinetics of α-Synuclein Ferrireductase Activity Identifies the Catalytically Competent Species.

Biochemistry - 16 May 2017

McDowall Jennifer S, Ntai Ioanna, Hake Jonathon, Whitley Paul R, Mason Jody M, Pudney Christopher R, Brown David R

Abstract excerpt

α-Synuclein (α-syn) is a cytosolic protein known for its association with neurodegenerative diseases, including Parkinson's disease and other synucleinopathies. The potential cellular function of α-synuclein may be of consequence for understanding the pathogenesis of such diseases. Previous work has suggested that α-synuclein can catalyze the reduction of iron as a ferrireductase. We performed a detailed analysis...

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PMID: 28452474
DOI: 10.1021/acs.biochem.7b00257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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