Article
α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer.
The Journal of biological chemistry - 4 May 2012
Fauvet Bruno, Mbefo Martial K, Fares Mohamed-Bilal, Desobry Carole, Michael Sarah, Ardah Mustafa T, Tsika Elpida, Coune Philippe, Prudent Michel, Lion Niels, Eliezer David, Moore Darren J, Schneider Bernard, Aebischer Patrick, El-Agnaf Omar M, Masliah Eliezer, Lashuel Hilal A
Abstract excerpt
Since the discovery and isolation of α-synuclein (α-syn) from human brains, it has been widely accepted that it exists as an intrinsically disordered monomeric protein. Two recent studies suggested that α-syn produced in Escherichia coli or isolated from mammalian cells and red blood cells exists predominantly as a tetramer that is rich in α-helical structure (Bartels, T., Choi, J. G., and Selkoe, D. J. (2011)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.