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Article

Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation.

Proceedings of the National Academy of Sciences of the United States of America - 2 Nov 2010

Anderson Valerie L, Ramlall Trudy F, Rospigliosi Carla C, Webb Watt W, Eliezer David

Abstract excerpt

Because oligomers and aggregates of the protein α-synuclein (αS) are implicated in the initiation and progression of Parkinson's disease, investigation of various αS aggregation pathways and intermediates aims to clarify the etiology of this common neurodegenerative disorder. Here, we report the...

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Identifiers

PMID: 20947801
DOI: 10.1073/pnas.1012336107
PMCID: PMC2973859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20947801-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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