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Article

Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses.

eNeuro - 1 Jan 2020

Pandian Swarna, Zhao Jian-Ping, Murata Yasunobu, Bustos Fernando J, Tunca Cansu, Almeida Ramiro D, Constantine-Paton Martha

Abstract excerpt

Myosin Va (MyoVa) is a plus-end filamentous-actin motor protein that is highly and broadly expressed in the vertebrate body, including in the nervous system. In excitatory neurons, MyoVa transports cargo toward the tip of the dendritic spine, where the postsynaptic density (PSD) is formed and maintained. MyoVa mutations in humans cause neurologic dysfunction, intellectual disability, hypomelanation, and death in...

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Identifiers

PMID: 33229412
DOI: 10.1523/ENEURO.0284-20.2020
PMCID: PMC7769881

Genes

PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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