Traumatic Brain Injury and Endocytosis: Reduced Rodent Hippocampal Endocytosis Proteins and Human Clathrin Light Chain Polymorphisms Are Associated with Impaired Neurological Outcomes After TBI.

Abstract excerpt

Traumatic brain injury (TBI) can result in enduring cognitive, emotional, and somatic impairments, which may be mediated in part by impaired synaptic function. Prior studies in experimental models of TBI have implicated molecular disturbances within the synaptic vesicular pool as a mediator of altered neurotransmission. Endocytosis maintains the pre-synaptic pool through recycling and replenishment of...

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