Article

PD-1 in hippocampal neurons regulates excitability, synaptic plasticity, and cognition

2021-07-14

Abstract excerpt

<h4>SUMMARY</h4> Immunotherapy using monoclonal antibodies against programmed cell death protein 1 (PD-1) demonstrated improved survival in cancer patients through immune activation. Here we show that functional PD-1 is expressed in mouse and primate hippocampal neurons and PD-1 inhibition improves cognition in physiological and pathological conditions. Mice lacking the Pdcd1 gene encoding PD-1 exhibit enhanced...

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Literature Corpus work: 383210ea-c247-5013-9a83-865d59f4d734
DOI: 10.1101/2021.07.13.451894

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