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Article

RhoA-ROCK Inhibition Reverses Synaptic Remodeling and Motor and Cognitive Deficits Caused by Traumatic Brain Injury.

Scientific reports - 6 Sept 2017

Mulherkar Shalaka, Firozi Karen, Huang Wei, Uddin Mohammad Danish, Grill Raymond J, Costa-Mattioli Mauro, Robertson Claudia, Tolias Kimberley F

Abstract excerpt

Traumatic brain injury (TBI) causes extensive neural damage, often resulting in long-term cognitive impairments. Unfortunately, effective treatments for TBI remain elusive. The RhoA-ROCK signaling pathway is a potential therapeutic target since it is activated by TBI and can promote the retraction of dendritic spines/synapses, which are critical for information processing and memory storage. To test this...

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Identifiers

PMID: 28878396
DOI: 10.1038/s41598-017-11113-3
PMCID: PMC5587534

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