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Article

Viral transduction of renin rapidly establishes persistent hypertension in diverse murine strains.

American journal of physiology. Regulatory, integrative and comparative physiology - 1 Sept 2015

Harlan Shannon M, Ostroski Robert A, Coskun Tamer, Yantis Loudon D, Breyer Matthew D, Heuer Josef G

Abstract excerpt

Mice provide a unique platform to dissect disease pathogenesis, with the availability of recombinant inbred strains and diverse genetically modified strains. Leveraging these reagents to elucidate the mechanisms of hypertensive tissue injury has been hindered by difficulty establishing persistent hypertension in these inbred lines. ANG II infusion provides relatively short-term activation of the...

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Identifiers

PMID: 26108870
DOI: 10.1152/ajpregu.00106.2015

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ANG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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