Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28.

G3 (Bethesda, Md.) - 7 Jun 2017

Zimmermann Christine, Garcia Ignacio, Omerzu Manja, Chymkowitch Pierre, Zhang Beibei, Enserink Jorrit M

Abstract excerpt

Cdk1 (Cdc28 in yeast) is a cyclin-dependent kinase (CDK) essential for cell cycle progression and cell division in normal cells. However, CDK activity also underpins proliferation of tumor cells, making it a relevant study subject. While numerous targets and processes regulated by Cdc28 have been identified, the exact functions of Cdc28 are only partially understood. To further explore the functions of Cdc28, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CDC2-CDC28 Kinases
Share to Cell Cycle
Share to DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epistasis, Genetic

Share to Gene Expression Regulation, Fungal

Share to Gene Regulatory Networks

Share to Recombinant Fusion Proteins

Share to Synthetic Lethal Mutations

Source

Open in PubMed Open full text

Identifiers

PMID: 28428242
DOI: 10.1534/g3.117.042317
PMCID: PMC5473755

Genes

CDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mapping the Synthetic Dosage Lethality Network of CDK1/CDC28.PMID 28428242Read ↗

A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.Semantic proximity Read ↗

Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategySemantic proximity Read ↗

A Synthetic Dosage Lethal Genetic Interaction Between CKS1B and PLK1 Is Conserved in Yeast and Human Cancer CellsSemantic proximity Read ↗

Functional Analysis of Kinases and Transcription Factors in Saccharomyces cerevisiae Using an Integrated Overexpression Library.Semantic proximity Read ↗

Cyclin-dependent kinasesSemantic proximity Read ↗

Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.Semantic proximity Read ↗

Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell LinesSemantic proximity Read ↗

Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.Semantic proximity Read ↗

Functional wiring of the yeast kinome revealed by global analysis of genetic network motifs.Semantic proximity Read ↗

Systematic over-expression screens for chromosome instability identify conserved dosage chromosome instability genes in yeast and human tumorsSemantic proximity Read ↗

A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.Semantic proximity Read ↗

Genome-wide survey of protein kinases required for cell cycle progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.