Article
A chemical-genetic screen to unravel the genetic network of CDC28/CDK1 links ubiquitin and Rad6-Bre1 to cell cycle progression.
Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 2011
Zimmermann Christine, Chymkowitch Pierre, Eldholm Vegard, Putnam Christopher D, Lindvall Jessica M, Omerzu Manja, Bjørås Magnar, Kolodner Richard D, Enserink Jorrit M
Abstract excerpt
Cyclin-dependent kinases (CDKs) control the eukaryotic cell cycle, and a single CDK, Cdc28 (also known as Cdk1), is necessary and sufficient for cell cycle regulation in the budding yeast Saccharomyces cerevisiae. Cdc28 regulates cell cycle-dependent processes such as transcription, DNA replication and repair, and chromosome segregation. To gain further insight into the functions of Cdc28, we performed a...
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