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Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

10 Jan 2021

Abstract excerpt

Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical practice. Increasing evidence suggests that CDKs, constituting a kinase family predominantly involved in cell cycle control, are synthetic lethal factors when combined...

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Identifiers

PMID: 34589394
DOI: 10.1016/j.apsb.2021.01.002

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