Article
The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma.
Oncotarget - 25 Apr 2017
Stein Caleb K, Pawlyn Charlotte, Chavan Shweta, Rasche Leo, Weinhold Niels, Corken Adam, Buros Amy, Sonneveld Pieter, Jackson Graham H, Landgren Ola, Mughal Tariq, He Jie, Barlogie Bart, Bergsagel P Leif, Davies Faith E, Walker Brian A, Morgan Gareth J
Abstract excerpt
We examined a set of 805 cases that underwent DNA sequencing using the FoundationOne Heme (F1H) targeted sequencing panel and gene expression profiling. Known and likely variant calls from the mutational data were analyzed for significant associations with gene expression defined translocation cyclin D (TC) molecular subgroups. The spectrum of KRAS, NRAS, and BRAF codon mutations varied across subgroups with NRAS...
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