Article
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Nov 2015
Walker Brian A, Boyle Eileen M, Wardell Christopher P, Murison Alex, Begum Dil B, Dahir Nasrin M, Proszek Paula Z, Johnson David C, Kaiser Martin F, Melchor Lorenzo, Aronson Lauren I, Scales Matthew, Pawlyn Charlotte, Mirabella Fabio, Jones John R, Brioli Annamaria, Mikulasova Aneta, Cairns David A, Gregory Walter M, Quartilho Ana, Drayson Mark T, Russell Nigel, Cook Gordon, Jackson Graham H, Leleu Xavier, Davies Faith E, Morgan Gareth J
Abstract excerpt
PURPOSE: At the molecular level, myeloma is characterized by copy number abnormalities and recurrent translocations into the immunoglobulin heavy chain locus. Novel methods, such as massively parallel sequencing, have begun to describe the pattern of tumor-acquired mutations, but their clinical relevance has yet to be established. METHODS: We performed whole-exome sequencing for 463 patients who presented with...
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