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Article

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.

Blood - 9 Aug 2018

Walker Brian A, Mavrommatis Konstantinos, Wardell Christopher P, Ashby T Cody, Bauer Michael, Davies Faith E, Rosenthal Adam, Wang Hongwei, Qu Pingping, Hoering Antje, Samur Mehmet, Towfic Fadi, Ortiz Maria, Flynt Erin, Yu Zhinuan, Yang Zhihong, Rozelle Dan, Obenauer John, Trotter Matthew, Auclair Daniel, Keats Jonathan, Bolli Niccolo, Fulciniti Mariateresa, Szalat Raphael, Moreau Philippe, Durie Brian, Stewart A Keith, Goldschmidt Hartmut, Raab Marc S, Einsele Hermann, Sonneveld Pieter, San Miguel Jesus, Lonial Sagar, Jackson Graham H, Anderson Kenneth C, Avet-Loiseau Herve, Munshi Nikhil, Thakurta Anjan, Morgan Gareth J

Abstract excerpt

Understanding the profile of oncogene and tumor suppressor gene mutations with their interactions and impact on the prognosis of multiple myeloma (MM) can improve the definition of disease subsets and identify pathways important in disease pathobiology. Using integrated genomics of 1273 newly diagnosed patients with MM, we identified 63 driver genes, some of which are novel, including IDH1, IDH2, HUWE1, KLHL6,...

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Source

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Identifiers

PMID: 29884741
DOI: 10.1182/blood-2018-03-840132
PMCID: PMC6097138

Genes

DIS3
ATM
BRAF
CCND1
FGFR3
HUWE1
IDH1
IDH2
KLHL6
MAF
MYC
PRKD2
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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