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Article

Intraclonal heterogeneity and distinct molecular mechanisms characterize the development of t(4;14) and t(11;14) myeloma.

Blood - 2 Aug 2012

Walker Brian A, Wardell Christopher P, Melchor Lorenzo, Hulkki Sanna, Potter Nicola E, Johnson David C, Fenwick Kerry, Kozarewa Iwanka, Gonzalez David, Lord Christopher J, Ashworth Alan, Davies Faith E, Morgan Gareth J

Abstract excerpt

We have used whole exome sequencing to compare a group of presentation t(4;14) with t(11;14) cases of myeloma to define the mutational landscape. Each case was characterized by a median of 24.5 exonic nonsynonymous single-nucleotide variations, and there was a consistently higher number of mutati...

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Source

Identifiers

PMID: 22573403
DOI: 10.1182/blood-2012-03-412981

Genes

BRAF
DIS3
DNAH5
KRAS
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22573403-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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