BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma.

doi:10.1158/1078-0432.CCR-19-1507

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2020

Boyle Eileen M, Ashby Cody, Tytarenko Ruslana G, Deshpande Shayu, Wang Hongwei, Wang Yan, Rosenthal Adam, Sawyer Jeffrey, Tian Erming, Flynt Erin, Hoering Antje, Johnson Sarah K, Rutherford Michael W, Wardell Christopher P, Bauer Michael A, Dumontet Charles, Facon Thierry, Thanendrarajan Sharmilan, Schinke Carolina D, Zangari Maurizio, van Rhee Frits, Barlogie Bart, Cairns David, Jackson Graham, Thakurta Anjan, Davies Faith E, Morgan Gareth J, Walker Brian A

Abstract excerpt

PURPOSE: Copy-number changes and translocations have been studied extensively in many datasets with long-term follow-up. The impact of mutations remains debated given the short time to follow-up of most datasets. EXPERIMENTAL DESIGN: We performed targeted panel sequencing covering 125 myeloma-specific genes and the loci involved in translocations in 223 newly diagnosed myeloma samples recruited into one of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Combined Chemotherapy Protocols

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Exosome Multienzyme Ribonuclease Complex

Share to Follow-Up Studies

Share to Multiple Myeloma

Share to Prognosis

Share to Proto-Oncogene Proteins B-raf

Share to Survival Rate

Source

Open in PubMed

Identifiers

PMID: 31988198
DOI: 10.1158/1078-0432.CCR-19-1507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF and DIS3 Mutations Associate with Adverse Outcome in a Long-term Follow-up of Patients with Multiple Myeloma.PMID 31988198Read ↗

Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.Semantic proximity Read ↗

Novel genomic findings in multiple myeloma identified through routine diagnostic sequencingSemantic proximity Read ↗

Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma.Semantic proximity Read ↗

A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysisSemantic proximity Read ↗

Mutations of ARID1B, PIK3C2B, KMT2B, and FAT1 genes influence clinical outcome in newly diagnosed myeloma.Semantic proximity Read ↗

Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy.Semantic proximity Read ↗

Genomic Basis of Multiple Myeloma Subtypes from the MMRF CoMMpass StudySemantic proximity Read ↗

Functional Impact of Genomic Complexity on the Transcriptome of Multiple MyelomaSemantic proximity Read ↗

Bi-allelic inactivation is more prevalent at relapse in multiple myeloma, identifying RB1 as an independent prognostic markerSemantic proximity Read ↗

Effect of MAPK activation via mutations in NRAS, KRAS and BRAF on clinical outcome in newly diagnosed multiple myeloma.Semantic proximity Read ↗

Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors.Semantic proximity Read ↗

Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.