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Article

Molecular pathogenesis and a consequent classification of multiple myeloma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Sept 2005

Bergsagel P Leif, Kuehl W Michael

Abstract excerpt

There appear to be two pathways involved in the pathogenesis of premalignant non-immunoglobulin M (IgM) monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma (MM). Nearly half of tumors are nonhyperdiploid, and mostly have one of five recurrent IgH translocations: 16% 11q13 (CCN D1), 3% 6p21 (CCN D3), 5% 16q23 (MAF), 2% 20q12 (MAFB), and 15% 4p16 (FGFR3 and MMSET). The remaining...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Multiple Myeloma

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Source

Identifiers

PMID: 16155016
DOI: 10.1200/JCO.2005.05.021

Genes

MAF
FGFR3
MAFB
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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