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Article

GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans.

The Journal of cell biology - 5 Jun 2017

Yin Jianhua, Huang Yaling, Guo Pengfei, Hu Siqi, Yoshina Sawako, Xuan Nan, Gan Qiwen, Mitani Shohei, Yang Chonglin, Wang Xiaochen

Abstract excerpt

Apoptotic cells generated by programmed cell death are engulfed by phagocytes and enclosed within plasma membrane-derived phagosomes. Maturation of phagosomes involves a series of membrane-remodeling events that are governed by the sequential actions of Rab GTPases and lead to formation of phagolysosomes, where cell corpses are degraded. Here we identified gop-1 as a novel regulator of apoptotic cell clearance in...

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Identifiers

PMID: 28424218
DOI: 10.1083/jcb.201610001
PMCID: PMC5461019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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