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Live-cell imaging in Caenorhabditis elegans reveals the distinct roles of dynamin self-assembly and guanosine triphosphate hydrolysis in the removal of apoptotic cells.

Molecular biology of the cell - 15 Feb 2010

He Bin, Yu Xiaomeng, Margolis Moran, Liu Xianghua, Leng Xiaohong, Etzion Yael, Zheng Fei, Lu Nan, Quiocho Florante A, Danino Dganit, Zhou Zheng

Abstract excerpt

Dynamins are large GTPases that oligomerize along membranes. Dynamin's membrane fission activity is believed to underlie many of its physiological functions in membrane trafficking. Previously, we reported that DYN-1 (Caenorhabditis elegans dynamin) drove the engulfment and degradation of apoptotic cells through promoting the recruitment and fusion of intracellular vesicles to phagocytic cups and phagosomes, an...

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Identifiers

PMID: 20016007
DOI: 10.1091/mbc.e09-05-0440
PMCID: PMC2820425

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