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Article

The Atg6/Vps30/Beclin 1 ortholog BEC-1 mediates endocytic retrograde transport in addition to autophagy in C. elegans.

Autophagy - 1 Apr 2011

Ruck Alexander, Attonito John, Garces Kelly T, Núnez Lizbeth, Palmisano Nicholas J, Rubel Zahava, Bai Zhiyong, Nguyen Ken C Q, Sun Lei, Grant Barth D, Hall David H, Meléndez Alicia

Abstract excerpt

Autophagy and endocytosis are dynamic and tightly regulated processes that contribute to many fundamental aspects of biology including survival, longevity, and development. However, the molecular links between autophagy and endocytosis are not well understood. Here, we report that BEC-1, the C. elegans ortholog of Atg6/Vps30/Beclin1, a key regulator of the autophagic machinery, also contributes to endosome...

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PMID: 21183797
DOI: 10.4161/auto.7.4.14391
PMCID: PMC3108013

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