Article
Autophagy genes promote apoptotic cell corpse clearance.
Autophagy - 1 Aug 2012
Zou Wei, Wang Xiaochen, Vale Ronald D, Ou Guangshuo
Abstract excerpt
Autophagy is a catabolic process through which damaged organelles and protein aggregates are delivered to lysosomes for degradation. Autophagy genes are reported to promote exposure of "eat me" signals on the surface of apoptotic cells, but whether they function in engulfing cells is not clear. Recently, we found that the autophagy mutants atg-18 and epg-5 are defective in removing apoptotic cells derived from...
Topics
- Animals
- Apoptosis
- Autophagy
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Lineage
- Genes, Helminth
- Lysosomes
- Mutation