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Article

MPEG1/perforin-2 mutations in human pulmonary nontuberculous mycobacterial infections

19 Apr 2017

Abstract excerpt

Perforin-2 is a highly conserved pore-forming protein encoded by macrophage expressed gene 1 (MPEG1). A number of studies have shown that Perforin-2-deficient mice are unable to survive following a bacterial challenge that is nonlethal in WT mice. There is also recent evidence that Mpeg1+/- heterozygous mice display an intermediate killing ability compared with Mpeg1 WT and Mpeg1-/- mice. Despite these in vivo...

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PMID: 28422754
DOI: 10.1172/jci.insight.89635

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