Article

Perforin-2 is dispensable for host defense against <i>Aspergillus fumigatus</i> and <i>Candida albicans</i>

2024-09-25

Abstract excerpt

<h4>ABSTRACT</h4> Myeloid phagocytes are essential for antifungal immunity against pulmonary Aspergillus fumigatus and systemic Candida albicans infections. However, the molecular mechanisms underlying fungal clearance by phagocytes remain incompletely understood. In this study, we investigated the role of perforin-2 ( Mpeg1 ) in antifungal immunity. We found that Mpeg1 -/- mice generated on a mixed C57BL/6J-...

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Literature Corpus work: d823f24e-b8b1-5ee8-b42d-21fc7edeffcc
DOI: 10.1101/2024.09.23.614582

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