Article
Tuberculosis in otherwise healthy adults with inherited TNF deficiency.
Nature - 1 Sept 2024
Arias Andrés A, Neehus Anna-Lena, Ogishi Masato, Meynier Vincent, Krebs Adam, Lazarov Tomi, Lee Angela M, Arango-Franco Carlos A, Yang Rui, Orrego Julio, Corcini Berndt Melissa, Rojas Julian, Li Hailun, Rinchai Darawan, Erazo-Borrás Lucia, Han Ji Eun, Pillay Bethany, Ponsin Khoren, Chaldebas Matthieu, Philippot Quentin, Bohlen Jonathan, Rosain Jérémie, Le Voyer Tom, Janotte Till, Amarajeeva Krishnajina, Soudée Camille, Brollo Marion, Wiegmann Katja, Marquant Quentin, Seeleuthner Yoann, Lee Danyel, Lainé Candice, Kloos Doreen, Bailey Rasheed, Bastard Paul, Keating Narelle, Rapaport Franck, Khan Taushif, Moncada-Vélez Marcela, Carmona María Camila, Obando Catalina, Alvarez Jesús, Cataño Juan Carlos, Martínez-Rosado Larry Luber, Sanchez Juan P, Tejada-Giraldo Manuela, L'Honneur Anne-Sophie, Agudelo María L, Perez-Zapata Lizet J, Arboleda Diana M, Alzate Juan Fernando, Cabarcas Felipe, Zuluaga Alejandra, Pelham Simon J, Ensser Armin, Schmidt Monika, Velásquez-Lopera Margarita M, Jouanguy Emmanuelle, Puel Anne, Krönke Martin, Ghirardello Stefano, Borghesi Alessandro, Pahari Susanta, Boisson Bertrand, Pittaluga Stefania, Ma Cindy S, Emile Jean-François, Notarangelo Luigi D, Tangye Stuart G, Marr Nico, Lachmann Nico, Salvator Hélène, Schlesinger Larry S, Zhang Peng, Glickman Michael S, Nathan Carl F, Geissmann Frédéric, Abel Laurent, Franco José Luis, Bustamante Jacinta, Casanova Jean-Laurent, Boisson-Dupuis Stéphanie
Abstract excerpt
Severe defects in human IFNγ immunity predispose individuals to both Bacillus Calmette-Guérin disease and tuberculosis, whereas milder defects predispose only to tuberculosis1. Here we report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant. Neither has any other clinical phenotype and both mount normal clinical and biological inflammatory responses....
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