Article

Perforin-2 Permeabilizes the Envelope of Phagocytosed Bacteria

2018-03-02

Abstract excerpt

Perforin-2, the product of the MPEG1 gene, limits the spread and dissemination of bacterial pathogens in vivo. It is highly expressed in murine and human phagocytes, and macrophages lacking Perforin-2 are compromised in their ability to kill phagocytosed bacteria. In this study we used Salmonella typhimurium as a model intracellular pathogen to elucidate the mechanism of Perforin-2‘s bactericidal activity. In vi...

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Literature Corpus work: 241c0e3b-bfef-5025-b40b-38c6187e1f6f
DOI: 10.1101/274878

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