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Host genetic factors and mycobacterial infections: lessons from single gene disorders affecting innate and adaptive immunity.

Microbes and infection - 1 Apr 2006

Doffinger Rainer, Patel Smita Y, Kumararatne Dinakantha S

Abstract excerpt

This review summarizes the association of increased susceptibility to mycobacterial disease in patients with genetic defects affecting innate and adaptive immunity. The optimum function of CD4 T-cell and macrophage function is critically important for immunity against mycobacteria. Antibody, complement and neutrophil function is not required for effective anti-mycobacterial immunity.

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Identifiers

PMID: 16520078
DOI: 10.1016/j.micinf.2005.10.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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