Article
Cutting edge: mutation of Francisella tularensis mviN leads to increased macrophage absent in melanoma 2 inflammasome activation and a loss of virulence.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2010
Ulland Tyler K, Buchan Blake W, Ketterer Margaret R, Fernandes-Alnemri Teresa, Meyerholz David K, Apicella Michael A, Alnemri Emad S, Jones Bradley D, Nauseef William M, Sutterwala Fayyaz S
Abstract excerpt
The mechanisms by which the intracellular pathogen Francisella tularensis evades innate immunity are not well defined. We have identified a gene with homology to Escherichia coli mviN, a putative lipid II flippase, which F. tularensis uses to evade activation of innate immune pathways. Infection of mice with a F. tularensis mviN mutant resulted in improved survival and decreased bacterial burdens compared to...
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