Mycobacterium tuberculosis inhibits human innate immune responses via the production of TLR2 antagonist glycolipids

Abstract excerpt

Significance To secure their colonization and survival, pathogens have evolved tactics to undermine host immune responses. Most particularly, Mycobacterium tuberculosis inhibits the activation of macrophages, one of whose roles is to recognize and kill invading microorganisms. Here, we used a library of M. tuberculosis mutants to infect macrophages and uncover molecular mechanisms by which the pathogen modulates...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Immune Response and Inflammation
• Share to Pneumocystis jirovecii pneumonia detection and treatment
• Share to Tuberculosis Research and Epidemiology