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Article

Dual phenotypes in recurrent astrocytoma, IDH-mutant; coexistence of IDH-mutant and IDH-wildtype components: a case report with genetic and epigenetic analysis.

Acta neuropathologica communications - 26 Oct 2024

Yamaguchi Junya, Ohka Fumiharu, Seki Masafumi, Motomura Kazuya, Deguchi Shoichi, Shiba Yoshiki, Okumura Yuka, Kibe Yuji, Shimizu Hiroki, Maeda Sachi, Takido Yuhei, Yamamoto Ryo, Nakamura Akihiro, Karube Kennosuke, Saito Ryuta

Abstract excerpt

Mutations in the isocitrate dehydrogenase (IDH) gene are recognized as the key drivers in the oncogenesis of astrocytoma and oligodendroglioma. However, the significance of IDH mutation in tumor maintenance and malignant transformation has not been elucidated. We encountered a unique case of IDH-mutant astrocytoma that, upon malignant transformation, presented two distinct intratumoral components: one...

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Identifiers

PMID: 39456052
DOI: 10.1186/s40478-024-01879-9
PMCID: PMC11515116

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