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Article

Genetic and Epigenetic Features of Rapidly Progressing IDH-Mutant Astrocytomas.

Journal of neuropathology and experimental neurology - 1 Jul 2018

Richardson Timothy E, Sathe Adwait Amod, Kanchwala Mohammed, Jia Gaoxiang, Habib Amyn A, Xiao Guanghua, Snuderl Matija, Xing Chao, Hatanpaa Kimmo J

Abstract excerpt

IDH-mutant astrocytomas are significantly less aggressive than their IDH-wildtype counterparts. We analyzed The Cancer Genome Atlas dataset (TCGA) and identified a small group of IDH-mutant, WHO grade II-III astrocytomas (n = 14) with an unexpectedly poor prognosis characterized by a rapid progression to glioblastoma and death within 3 years of the initial diagnosis. Compared with IDH-mutant tumors with the...

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Identifiers

PMID: 29741737
DOI: 10.1093/jnen/nly026
PMCID: PMC6005148

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APC
FANCB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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