Article
Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma.
Acta neuropathologica communications - 27 Nov 2023
Tateishi Kensuke, Miyake Yohei, Nakamura Taishi, Iwashita Hiromichi, Hayashi Takahiro, Oshima Akito, Honma Hirokuni, Hayashi Hiroaki, Sugino Kyoka, Kato Miyui, Satomi Kaishi, Fujii Satoshi, Komori Takashi, Yamamoto Tetsuya, Cahill Daniel P, Wakimoto Hiroaki
Abstract excerpt
In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive. Here, we report a unique case of IDH2 mutant astrocytoma, CNS WHO grade 3 that developed tumor progression. We performed a comprehensive genomic and epigenomic analysis for primary and recurrent tumors and found that both tumors harbored recurrent IDH2R172K and...
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