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Article

New Repeat Polymorphism in the AKT1 Gene Predicts Striatal Dopamine D2/D3 Receptor Availability and Stimulant-Induced Dopamine Release in the Healthy Human Brain.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 10 May 2017

Shumay Elena, Wiers Corinde E, Shokri-Kojori Ehsan, Kim Sung Won, Hodgkinson Colin A, Sun Hui, Tomasi Dardo, Wong Christopher T, Weinberger Daniel R, Wang Gene-Jack, Fowler Joanna S, Volkow Nora D

Abstract excerpt

The role of the protein kinase Akt1 in dopamine neurotransmission is well recognized and has been implicated in schizophrenia and psychosis. However, the extent to which variants in the AKT1 gene influence dopamine neurotransmission is not well understood. Here we investigated the effect of a newly characterized variant number tandem repeat (VNTR) polymorphism in AKT1 [major alleles: L- (eight repeats) and H-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins c-akt

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Identifiers

PMID: 28416594
DOI: 10.1523/JNEUROSCI.3155-16.2017
PMCID: PMC5426185

Genes

AKT1
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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