Article
Decreased VEGFR2 expression and increased phosphorylated Akt1 in the prefrontal cortex of individuals with schizophrenia.
Journal of psychiatric research - 1 Nov 2016
Hino Mizuki, Kunii Yasuto, Matsumoto Junya, Wada Akira, Nagaoka Atsuko, Niwa Shin-Ichi, Takahashi Hitoshi, Kakita Akiyoshi, Akatsu Hiroyasu, Hashizume Yoshio, Yamamoto Sakon, Yabe Hirooki
Abstract excerpt
The Akt signaling pathway involves various cellular processes and depends on extracellular stimuli. Since Akt signaling participates in cytoprotection, synapse plasticity, axon extension, and neurotransmission in the nervous system, alteration in Akt signaling might be a potential cause of schizophrenia. In this study, we performed multiplex fluorescent bead based immunoassays for members of the Akt signaling...
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