Article
DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder.
The international journal of neuropsychopharmacology - 1 Oct 2013
Savitz Jonathan, Hodgkinson Colin A, Martin-Soelch Chantal, Shen Pei-Hong, Szczepanik Joanna, Nugent Allison C, Herscovitch Peter, Grace Anthony A, Goldman David, Drevets Wayne C
Abstract excerpt
The A1 allele of the DRD2/ANKK1 Taq1A polymorphism (rs1800497) is associated with reduced striatal D(2/3) receptor binding in healthy individuals (Con) as well as depression and addiction. However, the effect of rs1800497 on D(2/3) receptor binding in depressed patients as well as the SNP's effect on D(2/3) binding during reward-associated dopamine release is unknown. Twelve unmedicated patients with major...
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