Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.

Translational psychiatry - 1 Mar 2016

Gluskin B S, Mickey B J

Abstract excerpt

The D2 dopamine receptor mediates neuropsychiatric symptoms and is a target of pharmacotherapy. Inter-individual variation of D2 receptor density is thought to influence disease risk and pharmacological response. Numerous molecular imaging studies have tested whether common genetic variants influence D2 receptor binding potential (BP) in humans, but demonstration of robust effects has been limited by small sample...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to DRD2 gene
Share to PER2 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Molecular Imaging

Share to Positron-Emission Tomography

Share to Receptors, Dopamine D2

Share to Tomography, Emission-Computed, Single-Photon

Source

Open in PubMed Open full text

Identifiers

PMID: 26926883
DOI: 10.1038/tp.2016.22
PMCID: PMC4872447

Genes

DRD2
PER2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation and dopamine D2 receptor availability: a systematic review and meta-analysis of human in vivo molecular imaging studies.PMID 26926883Read ↗

The impact of common dopamine D2 receptor gene polymorphisms on D2/3 receptor availability: C957T as a key determinant in putamen and ventral striatum.Semantic proximity Read ↗

DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder.Semantic proximity Read ↗

C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo.Semantic proximity Read ↗

C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity.Semantic proximity Read ↗

Polymorphisms in the dopamine D2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers.Semantic proximity Read ↗

Association between DRD2/ANKK1 TaqIA Allele Status and Striatal Dopamine D2/3 Receptor Availability in Alcohol Use Disorder.Semantic proximity Read ↗

The addiction-susceptibility TaqIA/Ankyrin repeat and kinase domain containing 1 kinase (ANKK1) controls reward and metabolism through dopamine receptor type 2 (DR2)-expressing neuronsSemantic proximity Read ↗

Prediction of striatal D2 receptor binding by DRD2/ANKK1 TaqIA allele status.Semantic proximity Read ↗

Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia.Semantic proximity Read ↗

Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.Semantic proximity Read ↗

Polymorphism in the ZNF804A Gene and Variation in D1 and D2/D3 Dopamine Receptor Availability in the Healthy Human Brain: A Dual Positron Emission Tomography Study.Semantic proximity Read ↗

D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.