Article
Genetic variation in AKT1 is linked to dopamine-associated prefrontal cortical structure and function in humans.
The Journal of clinical investigation - 1 Jun 2008
Tan Hao-Yang, Nicodemus Kristin K, Chen Qiang, Li Zhen, Brooke Jennifer K, Honea Robyn, Kolachana Bhaskar S, Straub Richard E, Meyer-Lindenberg Andreas, Sei Yoshitasu, Mattay Venkata S, Callicott Joseph H, Weinberger Daniel R
Abstract excerpt
AKT1-dependent molecular pathways control diverse aspects of cellular development and adaptation, including interactions with neuronal dopaminergic signaling. If AKT1 has an impact on dopaminergic signaling, then genetic variation in AKT1 would be associated with brain phenotypes related to cortical dopaminergic function. Here, we provide evidence that a coding variation in AKT1 that affects protein expression in...
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