Article
The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement.
PloS one - 1 Jan 2013
Savitz Jonathan, Hodgkinson Colin A, Martin-Soelch Chantal, Shen Pei-Hong, Szczepanik Joanna, Nugent Allison, Herscovitch Peter, Grace Anthony A, Goldman David, Drevets Wayne C
Abstract excerpt
Abnormalities of motivation and behavior in the context of reward are a fundamental component of addiction and mood disorders. Here we test the effect of a functional missense mutation in the dopamine 3 receptor (DRD3) gene (ser9gly, rs6280) on reward-associated dopamine (DA) release in the striatum. Twenty-six healthy controls (HCs) and 10 unmedicated subjects with major depressive disorder (MDD) completed two...
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