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Article

Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications.

Molecular psychiatry - 1 Oct 2012

Tan H Y, Chen A G, Chen Q, Browne L B, Verchinski B, Kolachana B, Zhang F, Apud J, Callicott J H, Mattay V S, Weinberger D R

Abstract excerpt

AKT1 controls important processes in medial temporal lobe (MTL) development and plasticity, but the impact of human genetic variation in AKT1 on these processes is not known in healthy or disease states. Here, we report that an AKT1 variant (rs1130233) previously associated with AKT1 protein expr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21788944
DOI: 10.1038/mp.2011.91
PMCID: PMC3449232

Genes

AKT1
BDNF
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21788944-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implications.PMID 21788944Read ↗

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AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatologySemantic proximity Read ↗

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