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Article

Genetic study of eight AKT1 gene polymorphisms and their interaction with DRD2 gene polymorphisms in tardive dyskinesia.

Schizophrenia research - 1 Dec 2008

Zai Clement C, Romano-Silva Marco A, Hwang Rudi, Zai Gwyneth C, Deluca Vincenzo, Müller Daniel J, King Nicole, Voineskos Aristotle N, Meltzer Herbert Y, Lieberman Jeffrey A, Potkin Steven G, Remington Gary, Kennedy James L

Abstract excerpt

Tardive dyskinesia (TD) is a motor adverse effect of chronic antipsychotic medication. It has been suggested to involve dopamine neurotransmission system changes. AKT1 acts downstream of the D(2) receptor that is blocked by all antipsychotics to some degree. The AKT1 gene has not been investigated in TD. We examined eight polymorphisms spanning the AKT1 gene and their association with TD in our schizophrenia...

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Source

Identifiers

PMID: 18838251
DOI: 10.1016/j.schres.2008.08.036

Genes

AKT1
DRD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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