Article
Epigenetic silencing of miR-490-3p promotes development of an aggressive colorectal cancer phenotype through activation of the Wnt/β-catenin signaling pathway.
Cancer letters - 28 Jun 2016
Zheng Kehong, Zhou Xinying, Yu Jinlong, Li Qiang, Wang Hui, Li Mingyi, Shao Ziyun, Zhang Feifei, Luo Yuhao, Shen Zetao, Chen Fei, Shi Fujun, Cui Chunhui, Zhao Dachuan, Lin Zhiqun, Zheng Wei, Zou Zhaowei, Huang Zonghai, Zhao Liang
Abstract excerpt
The Wnt/β-catenin pathway is known to contribute to colorectal cancer (CRC) progression, although little is known about the contribution of β-catenin on this process. We investigated the role of miR-490-3p, which was recently reported to suppress tumorigenesis through its effect on Wnt/β-catenin signaling. We found that hypermethylation of the miR-490-3p promoter down-regulates miR-490-3p expression in CRC...
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