Article
Neuroprotection and neuronal differentiation studies using substantia nigra dopaminergic cells derived from transgenic mouse embryos.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 1999
Son J H, Chun H S, Joh T H, Cho S, Conti B, Lee J W
Abstract excerpt
The major pathological lesion of Parkinson's disease (PD) is the selective cell death of dopaminergic (DA) neurons in substantia nigra (SN). Although the initial cause and subsequent molecular signaling mechanisms leading to DA cell death underlying the PD process remain elusive, brain-derived ne...
Topics
- 1-Methyl-4-phenylpyridinium
- Animals
- Autocrine Communication
- Biomarkers
- Brain-Derived Neurotrophic Factor
- Cell Differentiation
- Cell Line
- Dopamine
- Dopamine Agents
- Embryo, Mammalian
- Mice
- Mice, Transgenic
- Neurons
- Neuroprotective Agents
- Phenotype
- Substantia Nigra