Article

Engineering synucleinopathy-resistant human dopaminergic neurons by CRISPR-mediated mutation of the SNCA gene

2020-01-01

Abstract excerpt

An experimental treatment for Parkinson’s disease (PD) involved the transplantation of fetal midbrain tissue, a source of midbrain dopaminergic (mDA) progenitors, into the striatum of patients to restore dopaminergic innervation. Although clinical benefits were experienced by some patients, this heterogeneous and scarce source of tissue is not sustainable. Recently, mDA progenitors differentiated from human embryo...

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Literature Corpus work: 72fda8ed-74c2-5f8b-9e73-eccbd8e990b3
DOI: 10.7488/era/603

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