Article

Evaluation of <i>TH</i> -Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons

2020-07-10

Abstract excerpt

The focal and progressive degeneration of dopaminergic (DA) neurons in ventral midbrain has made Parkinson’s disease (PD) a particularly interesting target of cell-based therapies. However, ethical issues and limited tissue availability have so far hindered the widespread use of human fetal tissue in cell-replacement therapy. DA neurons derived from human pluripotent stem cells (hPSCs) offer unprecedented opportun...

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Literature Corpus work: 59748a5f-668c-5256-8b03-f5d07d36c051
DOI: 10.1101/2020.07.10.193870

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